14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity
نویسندگان
چکیده
منابع مشابه
Effects of /3-Adrenergic Stimulation
The L-type calcium current was investigated in normal and hypertrophied rat ventricular myocytes as a possible cause of the action potential lengthening that has been reported during hypertrophy. Regulation of the calcium current (lCa) by a ,B-adrenergic agonist (isoproterenol) was also analyzed since P-agonist-induced positive inotropy is less marked in hypertrophied heart. Left ventricular hy...
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The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival. In addition, ß-catenin is localized at the cell membrane and may influence the function of channels. The present study explored the possibility that ß-catenin participates in the regulation of the HERG K(+) channel. To this end, HERG ...
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Beta-adrenergic receptor-mediated cAMP or protein kinase A (PKA)-dependent modulation of cardiac potassium currents controls ventricular action potential duration (APD) at faster heart rates. HERG (KCNH2) gene mutations are associated with congenital long-QT syndrome (LQT2) and affect IKr activity, a key determinant in ventricular repolarization. Physical activity or emotional stress often trig...
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Institute for Neural Signal Transduction, ZMNH, Department of Pediatrics, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany, Leibniz Institute for Arteriosclerosis Research (LIFA) , Department of Cardiology and Angiology, Department of Medicine B, University of Münster, Germany, Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill M...
متن کاملC-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3ε
Beta-adrenergic receptor-mediated cAMP or protein kinase A (PKA)-dependent modulation of cardiac potassium currents controls ventricular action potential duration at faster heart rates. HERG (KCNH2) gene mutations are associated with congenital long-QT syndrome (LQT2) and affect IKr activity, a key determinant in ventricular repolarization. Physical activity or emotional stress often triggers l...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2002
ISSN: 1460-2075
DOI: 10.1093/emboj/21.8.1889